treatment for Type I diabetesA New Zealand doctor developed a method using the implant of microencapsulated pig islets, which could provide an answer to the problem of supply of insulin in people with the disease. What is Under the title “microencapsulated porcine islet transplantation: clinical experience and potential benefits in the metabolic control of type I diabetes”, Professor Dr. Robert Elliott provided a comprehensive overview of development of the disease worldwide, their evolution, treatment current and latest developments in the field.

In a meeting organized by the Foundation H. A. Barceló diabetologists doctors, clinicians and nutritionists, biotechnologists and biologists cell transplantation, occupational health sciences and students in the last years of the medical career were present at the conference on recent advances in research of diabetes type I, New Zealand was in Argentina.

Diabetes is a chronic disease of the fastest growing in the world today affects 246 million people. Between 10 and 15% for all cases of diabetes, corresponding to the Type 1 (insulin-dependent). The development of this type of diabetes is a consequence of an autoimmune phenomenon causing the destruction of pancreatic beta cells failing to produce insulin. At present, there is a single treatment can allow the survival of patients with this problem: the insulin that if it is the best alternative available, it is known is incapable of achieving perfect metabolic control of blood glucose.

Advances in research
Allogeneic is known that immunosuppressive Intrahepatic is clinically used in severe hypoglycemia but not the response to treatment of type 1 diabetes. It turns out that insulin-producing cells derived from a stem cell is in its infancy, can overcome the supply problem but not the total treatment. The same applies to genetically altered cells (non-islet) for the production of insulin in demand.

Faced with the imperfection of insulin that leads to complications of immunosuppression, Prof. Dr. Elliott developed a method using the implant of newborn pig islets microencapsulated (ICRNm) in alginate. These islands provide an answer to the problem of supply and would be a potential for implants without immune suppressant. They operate in a self-regulating, secreting insulin efficiently, improving the metabolic control of blood sugar, achieving near-normal levels of glycosylated hemoglobin and avoiding the appearance of complications of diabetes.

Dr. Elliott and his team used the pigs on the Auckland Islands to develop this method, since they are free from contamination and damage. The first transplant was performed in Russia in 1997.

During his presentation, Dr. Elliott explained the prerequisites of this practice, the ideal characteristics of the capsules and materials to use in the process, methods for the preparation of the transplant, the release criteria, models for the immune rejection and efficiency and regulatory issues.

He also presented the results of studies in diabetic rodents and primates in addition to the detection of porcine insulin in clinical studies today that the expert is carrying out in Russia and New Zealand to study the safety and efficacy of this treatment. This investigation is in phase 2 study in Argentina.

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